Fixation on Histology

Gone With the Wind - Disaster and Disease

Figure 1. Tornado levels on the Enhanced Fujita scaleTen years ago, at 5.17pm on the evening of Sunday 22nd May 2011, the National Weather Service issued a tornado warning for an area near the Missouri - Kansas state line. In response, the civil defense sirens were activated and at 5.34pm, the tornado touched down gently at an EF0 level of intensity (Figure 1). By the time it dissipated some 38 minutes later, it had reached speeds of more than 200 miles per hour (EF5 level) and devastated the city of Joplin, Missouri. With a total track length of more than 20 miles and a width of almost one mile, this tornado was unusual in that it intensified very quickly.

Within a short time, entire neighborhoods were destroyed, and the residents of Joplin had endured showers of debris hurled at them at unbelievable speeds. With 158 deaths and damage amounting to 2.8 billion American dollars, it ranked as the costliest single tornado in the history of the United States (Figure 2). In the weeks that followed, medical staff began noticing something very strange among the injured.

Figure 2. Combined images showing the damage in Joplin following the tornado

Figure 3. The Apophysomyces trapeziformis fungusCuriously, flesh wounds were turning black with a white, fuzzy mold emerging from them. Samples were taken for culture and medical staff were shocked when they examined the results from the laboratory. Thirteen of the injured had become infected with a fungus that is seldom seen in humans. Belonging to one of the major groups of fungi, Apophysomyces trapeziformis is a parasitic fungus of the order Mucorales (Figure 3). By definition, these fungi survive on decaying and rotten vegetation and very rarely infect humans. When they do, they cause mucormycosis, a rare and devastating infection that can sometimes prove fatal. Although the disease can affect the skin following traumatic inoculation, it can also involve the brain and lungs and spread throughout the body. Incidentally, mucormycosis is currently at epidemic proportions in India as a consequence of the COVID pandemic where thousands of patients with compromised immune systems have been affected by the ‘black fungus’ disease.

Figure 4. Mucormycosis with blood vessel involvementUnder tornado conditions, infected debris injects the fungus at excessive speeds directly into human flesh. Once inside the body, the fungus infiltrates blood vessels where its filaments create clots that prevent the blood from flowing (Figure 4). As the tissue dies it blackens and often sprouts a white, fuzzy coat of mold. These fungal infections are generally treated with antifungal drugs and debridement (regular surgical removal of dead flesh). All thirteen of those infected had been in the zone of greatest destruction and had a high number of wounds and lacerations which correlates well with the rate of Apophysomyces infection. Of those infected, five patients died although it was uncertain whether the fungus was the primary cause of death as no autopsies were carried out. Cutaneous mucormycosis has been documented previously in the wake of other natural disasters. Following the volcanic eruption in Colombia in 1985 and the Indonesian tsunami in 2004, this fungus reared its ugly head by causing infections through penetrating trauma. The injuries associated with this fungus have been compared to those resulting from combat where increased rates of fungal-related traumas have been reported by military personnel.

You can catch Dr. Bryant at the 2021 NSH Convention where he will be presenting a workshop on large format tissue processing.

Written by Phil Bryant, PhD, Cardiff Metropolitan University

Further reading

1. Biotic environments supporting the persistence of clinically relevant Mucormycetes. Richardson MD & Rautemaa-Richardson R. Journal of Fungi 2020;6(1):4

2. Fungal diseases as neglected pathogens: A wake-up call to public health officials. Rodrigues ML & Nosanchuk JD. PLoS Neglected Tropical Diseases 2020;14(2):e0007964

3. Invasive fungal infections after natural disasters. Benedict K & Park BJ. Emerging Infectious Diseases 2014;20(3):349-355

4. Mucormycosis due to Apophysomyces species complex - 25 years' experience at a tertiary care hospital in southern India. Pamidimukkala U, Sudhaharan S et al. Medical Mycology 2020;58(4):425-433

5. Necrotizing cutaneous mucormycosis after a tornado in Joplin, Missouri, in 2011. Neblett Fanfair R, Benedict K et al. New England Journal of Medicine 2012;367(23):2214-2225